Best Bed Bug Spray in 2023

In this round-up, we have listed 5 best bed bug killer sprays in the market. This bed bug spray review features artificial chemical and organic based sprays are being listed and they are each great in its own way.

Bed bug sprays are a highly effective way to treat and kill bed bugs. It’s inexpensive, easy to apply and are perfect for spot treatment.

Here are the advantages and disadvantages of using bed bug sprays:

Pros of using Bed Bug Spray
  • Inexpensive
  • Easy to use
  • Great for spot treatment
  • Effectively kills on contact
  • Have organic & chemical options
Cons of using Bed Bug Spray
  • Smell can be overwhelming
  • Only kills on contact

Quick Note When Using Bed Bug Spray

  1. Know Where to Spray – Luggage brought from a trip as Bed bugs tend to travel with you back home, where they breed and spread all over the house. Usually hiding on floor carpets, window frames, inside cracks of walls, on the door and wooden floor, behind paintings or peeling off wallpaper. Furnitures, and soft pillows, mattresses and bed sheets where humans are inactive during the night.
  1. Repeat Application – All sprays work in the same way where they kill on contact. Even with products with residual effect, it’s better to apply spray a few times regardless of the infestation scale.

1Bed Bug Spray by EcoRaider Check Price
2Eco Defense Bed Bug Spray Check Price
3Ortho Home Defense Dual-Action Bed Bug Aerosol Spray Check Price
4Organic Bed Bug Killer Spray by MDX Concepts Check Price
5Harris Toughest Bed Bug Spray Check Price
6Hot Shot Bed Bug 17.5 oz Aerosol Spray Check Price

1) Bed Bug Spray by EcoRaider (with Extended Residual Protection)

The bed bug killer spray by EcoRaider is a certified USDA BioBased insecticide that is dermatologically safe, child and pet friendly; and can be used directly on mattress and box springs.

This all-natural product has been tested and proven by research entomologists (USDA IR4 PHP program) for eliminating bed bug infestations in public housing buildings and is recommend for treatment areas that are sensitive (i.e. schools, clinics, health-care facilities and public areas).

It’s non-toxic and can get rid of all types of bed bugs (including the ones resistant to bed bug insecticides), bedbugs in both the larval and adult stage. It also has a two-week residual effect.

Eco Raider uses a non-staining formula that does not leave marks on the furniture or floor.

  • Eco-friendly and non-toxic
  • Keeps killing for weeks
  • Green product
  • Field tested by research entomologists
  • Eliminates even resistant bed bugs
  • Destroys all stages of bed bugs
  • Causes no harm to pets and humans
  • Smell can be overwhelming

Side note: Unlike chemical pesticides, EcoRaider uses plant extracted active ingredients that cause immediate paralysis and death by attacking neuron receptor that only exists in invertebrates (i.e. insects), but do not affect vertebrates (i.e. humans, birds, animals and fish).

Tip: Try to apply treatment at areas that are ventilated

2) Eco Defense Bed Bug Spray

The Eco-defense bed bug killer spray kills on contact using a proprietary blend of natural, organic, and non-toxic ingredients that kill bed bugs in any stages of their life including adults, nymphs, and eggs.

It does not contain pesticides, uses chemicals or poisonous Ingredients, and can be applied directly to your mattress cover and sheets without fear of staining.

Eco Defense also offers a 60-day trial period with refund.

  • Non-toxic & Organic ingredients
  • Non-staining
  • Kills bed bugs in all stages
  • Pet and child safe
  • Money back guarantee
  • Strong smell

Tip: After drying completely, consider adding Harris Diatomaceous Earth Bed Bug Powder.

3) Ortho Home Defense Bed Bug Aerosol Spray (with Dual-Action)

Brand: Ortho

The Home defense dual-action bed bug killer by Ortho is an aerosol spray designed for indoor use. This fast-acting spray kills resistant bed bugs and their eggs on contact and stays effective for up to two weeks after treatment.

It can be used for spot treatment use on and around bed frame, luggage, mattress seams, and other areas with bed bug activity.

  • Also kill stink bugs, fleas & dust mites
  • Fast acting formula.
  • Long-lasting bed bug control
  • Fast-acting formula
  • Kills bed bugs and their eggs
  • Contains more toxic chemicals than all-natural sprays

Note: Do allow treatment area to dry for about 3 – 4 hours before going near, as this spray does uses more toxic chemicals than the all-natural sprays. Avoid direct contact with humans or pets.

#4 Organic Bed Bug Killer Spray by MDX Concepts

>> Best Organic Bed Bug Spray

This natural bed bug spray by MDX Concepts is formulated using essential oil and it works on almost all bedbug species. It uses peppermint oil as one of its main ingredients to effectively get rid of bed bugs without causing any unpleasant or artificial smell.

This organic bed bug spray is friendly to use around pets and children; and its stain-free content ensures that no stain marks are left after applications. 

  • Made with plant derived essential oils
  • Has naturally pleasant fragrance
  • Pet and child friendly
  • Stain-free

5) Harris Toughest Bed Bug Spray

Brand: Harris

The Harris bed bug spray is approved by the Environmental Protection Agency (EPA) for use in homes with pets and humans. Like other sprays featured in this list, it provides quick kill that knocks down bed bugs fast when sprayed directly

It is formulated to get rid of even the toughest bed bugs and eggs that have built up a resistance to pesticides (pyrethroid resistant). It also has long residual which continues to kill for up to 16 weeks after initial application.

The Harris spray is non-staining to fabrics when used according to label directions and features an odorless formula.

  • EPA Registered
  • Odorless formula
  • Non-staining formula
  • Long residual
  • Hose supplied on 1 gallon can be quite stiff

[May: PF Harris is America’s oldest EPA-registered company. It’s a reliable brand with more than 50 products to treat pest problems.]

>> Available in 32 ounces & 1 gallon

6) Hot Shot Bed Bug 17.5 oz Aerosol Spray

Brand: Hot Shot

The Hot Shot aerosol bed bug spray is designed for indoor use. It kills both bed bugs and bed bug eggs.

As opposed to other sprays listed, this spray is not designed to be applied on soft surfaces (i.e. beddings, fabrics) but specialise in spot treatment kill (i.e cracks & crevices around floorboards, bedboards and on the walls, night stand, drawers, picture frames and other wall hangings, door and window casings).

  • No unpleasant odor
  • Also works on ticks and fleas
  • Designed for Spot treatment
  • Can’t be applied to soft fabrics

Note: Be sure to wash the bed and blanket of doggie if treated as dogs can absorb the chemicals through their feet and by licking.

Tip: Allow treated surfaces to dry completely before using again. Re-apply after 2 weeks if necessary.


While Bed bug sprays are effective in killing the pesky pest, they only kill bugs that the spray comes in contact with. A portion of the bed bugs at home are hidden from our eyes (i.e in furniture, carpet, in the cracks of walls, on mattresses, and other locations).

>> Related article: Best Bed Bug Mattress Encasement

Only when combined with other bed bug treatment methods (i.e. steaming, vacuuming, use of diatomaceous earth) will the elimination be complete. Failing to use additional treatment methods to kill the bed bugs you can’t see can result in the hidden bed bugs reproducing.

We will leave you with this short clip from National Geographic about Bed Bugs:

Are you facing bed bugs problems at home? Which bed bug spray have you tried and are they effective? We would love to hear from you.